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Additionally, legislative changes in the United States and Europe have made it even more critical that drug developers ensure clinicians have adequate efficacy, safety, and dosing information to effectively prescribe appropriate medications to children.
Pediatric trials, however, are notoriously challenging with unique barriers to successful trial completion such as parental perceptions, motivations, and attitudes in relation to the benefit and burden of trial participation; a higher rate of early patient drop-out; and the inherent characteristics of the pediatric patient population. These barriers all contribute to reduced patient participation or retention and result in far fewer therapeutic advances for the pediatric cohort.
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